Recipient information

Risk estimation





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Recipient-specific values

Transplant-specific values

Prediction overview and visualization selection

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Mortality

Graft survival



Disclaimer: No Medical Advice. ALTHOUGH SOME CONTENT MAY BE PROVIDED BY INDIVIDUALS IN THE MEDICAL PROFESSION, YOU ACKNOWLEDGE THAT PROVISION OF SUCH CONTENT DOES NOT CREATE A MEDICAL PROFESSIONAL-PATIENT RELATIONSHIP AND DOES NOT CONSTITUTE AN OPINION, MEDICAL ADVICE, PROFESSIONAL DIAGNOSIS, SERVICE OR TREATMENT OF ANY CONDITION. Access to general information is provided for educational purposes only, through this site and links to other sites. Content is not recommended or endorsed by any doctor or healthcare provider. The information and Content provided are not substitutes for medical or professional care, and you should not use the information in place of a visit, call, consultation or the advice of your physician or other healthcare provider. You are liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product obtained through this site.

Information

KTOP allows the prediction of certain outcomes after kidney transplantations from brain-dead deceased donors. It estimates the risk of death during a certain timeframe after the operation as well as the cumulative incidence of organ failures and deaths with a functioning graft. All calculations are based on data from Eurotransplant, the largest international European organ allocation organization.

The basic calculator requires only patient-specific information, which is already available before a potential donor kidney has been identified. Its predictions are for the fixed timeframes of five and ten years.

The expert calculator requires transplant-specific values to achieve a higher prediction accuracy. It allows the entry of multiple values per risk factor as well as multiple timeframes and considers all possible entry combinations for prediction. Multiple numbers can be entered by separating them with a comma. After calculation, individual rows can be selected in the resulting dataframe to be visualized below.


Term explanations

CIT
Cold ischemia time - time period between initiation of donor in vivo cold organ preservation and cold storage in postmortal organ donation for transplantation until removal of the graft from the storage container and start of surgical anastomoses of the vessels
Cumulative incidence
Proportion of individuals who develop the outcome
ET allocation program
Indicates the Eurotransplant allocation program of the organ recipient (see ETKAS and ESP)
ETKAS
Eurotransplant kidney allocation system - the standard allocation system of Eurotransplant
ESP
Eurotransplant Senior Program - the allocation system of Eurotransplant reserved for recipients older than 64 years
HLA
Human leukocyte antigen - more matches indicate a better immunological fit between recipient and transplant
Transplant count
Number specifying if the transplant is a retransplantation or not

Reference
G. Miller, D.P. Ankerst, M.W. Kattan, N. Hüser, S. Vogelaar, I. Tieken, U. Heemann, V. Assfalg. Kidney Transplantation Outcome Predictions (KTOP): A Risk Prediction Tool for Kidney Transplants from Brain-dead Deceased Donors Based on a Large European Cohort, Eur Urol (2022), https://doi.org/10.1016/j.eururo.2021.12.008.


Affiliations

Technical University of Munich
TransplanTUM - Munich Transplant Center, Klinikum rechts der Isar
Department of Mathematics
Department of Life Science Systems, Munich Data Science Institute
Cleveland Clinic
Department of Quantitative Health Sciences
Eurotransplant International Foundation



Disclaimer: No Medical Advice. ALTHOUGH SOME CONTENT MAY BE PROVIDED BY INDIVIDUALS IN THE MEDICAL PROFESSION, YOU ACKNOWLEDGE THAT PROVISION OF SUCH CONTENT DOES NOT CREATE A MEDICAL PROFESSIONAL-PATIENT RELATIONSHIP AND DOES NOT CONSTITUTE AN OPINION, MEDICAL ADVICE, PROFESSIONAL DIAGNOSIS, SERVICE OR TREATMENT OF ANY CONDITION. Access to general information is provided for educational purposes only, through this site and links to other sites. Content is not recommended or endorsed by any doctor or healthcare provider. The information and Content provided are not substitutes for medical or professional care, and you should not use the information in place of a visit, call, consultation or the advice of your physician or other healthcare provider. You are liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product obtained through this site.